Spokane WA to Reno NV truck route

It's all truck friendly and a very easy run. Get on 139 out of Klamath Falls, then a left on 299 at Canby to Alturas, then 395 all the way to Reno. You can also take the Boise to Winnemucca to Reno route, but it's not really any faster.

 

Like @SteveScott said, 139, 299, and 395 is your best route.
Just watch out for cattle on the roadway at night. A lot of that country is open range and if you hit a cow you not only have truck damage, you just bought yourself a cow. Open range areas are supposed to posted but they often aren't.

 

What does a Road Kill Cow go for these days. May be cheaper than the grocery store beef!

 

Speaking from experience, if you hit a rancher's cow or steer it suddenly gets elevated from just a mangy old range cull to prime breeding stock. The price goes up accordingly.
Figure on at least
five or six hundred dollars. Plus your repair bill of course.

 

Could also take 31 across out of LaPine and hit 395 north of Lakeview. But I’m weird like that and enjoyed the no traffic when you get out around Christmas Valley.

 

Cows don’t fall under wild life in some insurance claims . If ever you hit one claim it’s a deer lol

 

Can’t run 395 south of Pendleton from Pilot Rock to John Day unless you’re 65ft.

Edit: route map no shows no limit on that stretch for 48ft trailers. Anything over 48ft is still limited to 65ft overall without a permit.

 

That 395 down to Reno gets real windy sometimes,when you see a bull hauler with his flashers on,you know it's bad.