Can rust jacking in-between double frame rails cause driveline issues?

So this is on my 99 pete 379. I bought the truck about 3 years ago and gave constantly had driveline issues. I've lost 4 or 5 driveshafts, 1 carrier bearing, had to replace the transmission and a rear end.
A little history first. The man I bought it from was a long time friend of the family. He was terminal with cancer and wanted his truck to go to a good home and I agreed to buy it. He had lost a driveshaft the winter before and said it needed the back half of the transmission rebuilt. He wanted to make sure that work got done before I bought it. So he sent it to the shop. He ended up passing away before it came back from the shop. Another friend drove it hone from the shop and there it sat for a year until his estate was settled and I was allowed to buy it.
The very first time I pulled a trailer with it I thought it was going to blow up the transmission. The transmission growled loudly. You had to yell to a passenger to hear you and forget the radio.
Then it started loosing driveshafts. I'd have the shaft rebalanced. ( I've now learned it's often times the shaft next to the one that came out that is the trouble maker). Yoke nuts would come loose. Then I started loosing gears so I replaced the transmission. I thought my growling days were over. NOPE, the new transmission growled the same. A carrier bearing and another drive shaft later, I took it to a shop to have all the angles checked out and the ride height checked. He found 1 wrong yoke and a few angles off a bit. He said it was better but still growled a little bit and still had a minor vibration but he could not find the cause.
It was better fir awhile but got bad again. Then I lost the front rear-end and my mind at this point.
I'm so paranoid now that I make the mechanic check the whole driveline every few weeks.
I've had a driver in it for awhile now. He's only had his license a year and is really green (3 clutch brakes in 3 weeks kind of green) I ended up driving the other day and it was awful. Growling, vibration, difficulties shifting. The mechanic found 2 bad u joints, a loose nut on the back of the transmission and upon further investigation a bad out put shaft bearing.
The front 2 shafts had never fallen out but one of them had side to side play on the splines. So I sent those out to be balanced. We are doing the back half of the transmission. The driveline guy asked me to bring him the other 2 shafts and the new yoke so he could balance everything together. I did. He called today and said one of the front ones was junk. One of the rear ones was out of round.
6 months ago I also replaced all the torque rods. I know I still have a broken spring mount. It's the little plate that sits on top thats cracked. I fixed one already and a week later the other one cracked.
We've checked all the wheels. I have not checked engine mounts ( I keep forgetting)
The truck has double frames up to the back of the cab. There is quite a bit of rust between them. I'm not sure exactly how much , I'm going to check tomorrow. So my question is, after all these details, could rust jacking be pushing the frame rails enough to cause something to not line up right that might be the root of my problem???
Again, I'm not a mechanic. I work on my truck with my mechanic so I learn as much as I can and I love to research stuff but I still come up with off the wall questions sometimes. So if rust jacking can't cause this please forgive me. Im just getting desperate for a solution. I was planning on replacing the frame rails within the next year with a single heavy duty rail. Ill do it sooner if this is the cause of my driveline issues.
Oh yeah, it needs a new clutch too but I believe that's driver related. I replaced the clutch when I put in the new transmission 2 years ago.